In addition to steam with proton, you can add :

• ProtonGE : it’s a modified version of Proton, if games don’t work with the default Proton versions you can try this one and sometimes it fixes the issue.
  • Don’t bother installing it manually, though, just install ProtonUpQt with your package manager, run it, and have it install the latest ProtonGE for you. Then you go in steam, in your game’s compatibility options, and you choose ProtonGE in the list. It’s not needed for most games, but it’s nice for those few cases where the game doesn’t work.
• Protontricks

AMD GPU is good, it means you won’t want to die installing Nvidia drivers if you choose Fedora.